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Smoking Cessation Drugs Chantix and Zyban for Quit Smoking Habit. By Anthony D'costa

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Smoking Cessation Drugs for Quit Smoking habit

As more and more reports about hazards of smoking come up, we become more determined to quit smoking. However, the hurdle is that smoking cessation is easier said than done. People try all their lives before they successfully quit smoking.

Smoking effects

Smoking is the highest preventable cause of death and every year millions of people die every year because of it. Smoking not only leads to death but also diminishes the quality of life. Many smokers do realise this but they are gripped into the habit so badly that in spite of readiness to quit smoking, they are unable to give up. This is because of nicotine addiction. Many medications have surfaced in the market to help people with nicotine addiction.

Which medicines are available?

In earlier days, herbal remedies and nicotine replacement therapies were available for smoking cessation. Hypnotherapy and counselling was also available to aid smoking cessation. However, all these methods had many limitations and had a very low success rate. Nowadays, two drugs are available, Chantix and Zyban, which are touted to have a higher success rate and very few limitations.

How they work?

Nicotine replacement therapy contains nicotine and works under the theory that substituting smokers from one form of nicotine to other will help them quit smoking. However, the problem is that a person does not actually withdraw from nicotine and can experience withdrawal symptoms once he stops taking the treatment and starts smoking again.

Herbal remedies are said to contain herbs that help in smoking cessation, however the truth behind this is not yet established. Counselling and hypnotherapy answer the psychological needs but do not address the physical addiction.

Zyban works by reducing withdrawal symptoms and Chantix works by reducing withdrawal symptoms, nicotine cravings, and pleasure a smoker gets while smoking.

Ingredients of medicines

Nicotine replacement therapies contain nicotine and herbal remedies contain ancient herbs. The active ingredient in Zyban is bupropion and in Chantix is varenicline.

Side effects of medicines

Some of the side effects of nicotine replacement therapies are as dizziness, headache, abdominal discomfort, nausea, and vomiting, indigestion and palpitations.

There are not many limitations of Zyban and Chantix. The main limitation of the two new smoking cessation drugs is that they cause undesirable effects on smoker.

Side effects of Zyban

Some of the side effects of Zyban are:

  • Dizziness
  • Anxiety and agitation
  • Depression
  • Dry mouth
  • Constipation
  • Abdominal pain
  • Nausea
  • Fever
  • Sweating
  • Rash or itching
  • Insomnia
  • Headache
  • Concentration disturbance


Side effects of Chantix
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16:44 - 2008-Mar-31 - comments {0} - post comment


Heparin Adverse Reactions and Heparin Symptoms By Peter Kent

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Recent reports of patients suffering from serious adverse reactions immediately after being given treatment with Baxter?’s heparin drug have caused considerable alarm among the public and also the medical community. 4 deaths have also been reported of patients who were given the china heparin drug, which indicates that the heparin adverse reactions may have assumed fatal proportions. Find out if you too are suffering from any heparin adverse reactions. If so, you need to consult with our expert team of heparin lawyers to know about just compensation. Heparin Side Effects Generally, various side effects and symptoms are associated with the use of the heparin drug. Some of these are:
  • Itching and burning sensation on the soles of the feet
  • Generalized hypersensitivity
  • Fever
  • Chills
  • Mild pain
  • Inflammation or redness of the skin
These are the common side effects of heparin. Some of the more serious side effects which are quite rare in nature include asthma, gangrene, osteoporosis (after prolonged use of heparin), hemorrhaging, heparin induced thrombosis (HIT), and pulmonary embolism (plugging of the arteries). Heparin Symptoms Beginning November 2007, reports started surfacing about patients, who had been given the Baxter heparin, suffering from uncommon adverse reactions. The unusually high number of reports about these adverse reactions to the heparin drug led to the investigation of the causes behind these adverse reactions. Although the exact causes are yet to be determined, the Baxter Company has in the meanwhile called for a heparin recall of existing lots of the drug from the markets. Here are the different heparin symptoms that people have reported to be suffering from after using the Baxter heparin drug:
  • Severe stomach pain and discomfort
  • Vomiting and nausea
  • Loose stools and blood in the stools
  • Rapid fall in blood pressure leading to low blood pressure
  • Pain in the chest
  • Accelerated heart rate
  • Fainting spells
  • Difficulties in breathing and shortness of breath
  • Swelling in the throat
  • Increased perspiration
  • Drug ineffectiveness
  • Watery eyes
  • ifficulty opening the mouth
  • Abnormal bleeding.
Some people have also suffered heparin shock and there have been 4 cases of death too. All these adverse reactions to the heparin drug have been observed in patients who were undergoing one of the following three medical treatments:
  • Invasive cardiovascular procedures
  • Dialysis for kidney failure
  • Apheresis procedures
The FDA has issued a press release advising customers to stop the use of Baxter heparin. However, if you have already been given the potentially harmful china heparin and have suffered adverse medical reactions due to it, you could be entitled to damages. Do consult with our heparin lawyers immediately!
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20:12 - 2008-Mar-30 - comments {0} - post comment


Tobacco Poses Threat To Mothers In Developing World

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U.S researchers said that pregnant women's exposure to tobacco in developing countries is growing at an alarming rate.

Women in developing countries and their children are increasingly breathing secondhand smoke in their homes and many more are beginning to experiment with smoking, increasing the risk of cancer, heart disease and illness not only for themsevles but also for their children.

Dr. Michele Bloch of the National Cancer Institute's Tobacco Control Research Branch, whose study appears in the American Journal of Public Health said, "Pregnant women's tobacco use and exposure to secondhand smoke threaten to impede or reverse ongoing efforts to improve maternal and child health in the developing world."

The study is the first to examine pregnant women's tobacco use, exposure to secondhand smoke and attitudes about tobacco use in many developing countries.

It involved 8,000 interviews with pregnant women at 10 study sites in nine countries, including Argentina, Uruguay, Ecuador, Brazil, Pakistan, Zambia and the Democratic Republic of the Congo.

The researchers found as many as 18 percent of pregnant women smoked cigarettes, up to one-third used smokeless tobacco and as many as half regularly breathed in secondhand smoke.

Bloch said these trends represent a major shift among women in developing countries, where historically about 9 percent of women used tobacco, due in part to strong cultural taboos.

Smoking is the leading cause of preventable death among women in developed countries, and Bloch said the findings offer a chance to intervene before women in the developing world match that grim statistic.

She added, "Latin America is where the epidemic of cigarette smoking is most advanced, particularly in Uruguay, where 78 percent of all pregnant women said they had ever tried a cigarette. In Argentina, 75 percent of pregnant women interviewed said they had tried smoking."

Smokeless tobacco was used by a third of the women in the Indian state of Orissa, while the highest levels of secondhand smoke exposure was found in Pakistan.

"Young children in Pakistan are frequently or always exposed to tobacco smoke indoors. The numbers were also high in Argentina, Brazil, Uruguay and one of the Indian states."

http://www.ash.org
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12:48 - 2008-Mar-25 - comments {0} - post comment


Foot Ulcer Types And Treatment Posted By : HutchPeter

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A skin ulcer is where an area of skin has broken down and you can see the underlying tissue. Most skin ulcers occur on the lower legs or feet. The skin normally heals quickly if it is cut. However, in some people with diabetes the skin on the feet does not heal so well and is prone to develop an ulcer. This can be even after a mild injury such as stepping on a small stone in your bare feet.

Types of Foot Ulcer

Venous ulcers are located below the knee and are primarily found on the inner part of the leg, just above the ankle.

The borders of a venous ulcer are usually irregularly shaped and the surrounding skin is often discolored and swollen. It may even feel warm or hot. The skin may appear shiny and tight, depending on the amount of edema (swelling). The skin may also have brown or purple discoloration about the lower leg, known as "stasis skin changes."

Neurotrophic (diabetic)

Neurotrophic ulcers are usually located at increased pressure points on the bottom of the feet. However, neurotrophic ulcers related to trauma can occur anywhere on the foot. They occur primarily in people with diabetes although they can affect anyone who has an impaired sensation of the feet.

Diabetes can cause damage to the nerve and vascular supply in the feet and legs. Patients with neuropathy have reduced or no sensation and, therefore, might be unaware of any trauma to their feet caused by ill-fitting footwear or an object in their shoes, such as a piece of glass, a stone or a drawing pin. Continued walking on an injured foot will damage it further and minor lesions can become more serious. A simple examination of the feet, feeling inside the shoes before wearing them and not walking barefoot can help to prevent minor injuries. Many of the patients attending the diabetes clinic are older and some cannot see, feel or reach their feet, which means that they are often unaware of any injuries.

Diabetic foot ulcers are caused by neuropathic (nerve) and vascular (blood vessel) complications of the disease.

Nerve damage due to diabetes causes altered or complete loss of feeling in the foot and/or leg. This is known as peripheral neuropathy. Pressure from shoes, cuts, bruises, or any injury to the foot may go unnoticed. The loss of protective sensation stops the patient from being warned that the skin is being injured and may result in skin loss, blisters and ulcers.

Treatment options for all ulcers may include:

Antibiotics, if an infection is present

Anti-platelet or anti-clotting medications to prevent a blood clot

Topical wound care therapies

Compression garments

As a rule, the better the control of your diabetes, the less likely you are to develop complications such as foot ulcers. Also, where appropriate, treatment of high blood pressure, high cholesterol level, and reducing any other risk factors will reduce your risk of diabetes complications. In particular, you are strongly advised to stop smoking if you smoke.

Our feet keep us balanced and carry our weight. In a lifetime they walk as much as going five times around the earth. We should look after our feet before any of these problems creep in. Some of the serious foot problems may need the attention of a doctor. So, prevention is always better than cure.


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12:43 - 2008-Mar-19 - comments {0} - post comment


NanoBio Corporation Successfully Completes Phase 2b Study In Herpes Labialis

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NanoBio Corporation reported top-level findings from its phase 2b study of NB-001, a topical lotion to treat herpes labialis (cold sores). The randomized, double-blind, vehicle- controlled study met its primary and secondary endpoints by demonstrating clear efficacy and safety in 482 patients.

NanoBio's uniquely formulated lotion resulted in faster healing of cold sores, at a rate never seen before by a topical product. The company's targeted phase 3 dose demonstrated highly statistically significant clinical efficacy in phase 2b at a magnitude comparable with or superior to what has been reported for the leading oral (systemic) anti-herpetic drugs on the market.

Additionally, NB-001 demonstrated an excellent safety profile, with no serious adverse events, significant skin irritation or systemic blood absorption. In contrast, leading oral systemic treatments for herpes labialis carry label warnings that include nausea, diarrhea, vomiting, rash and migraine.

"Through this trial, we have confirmed that NB-001 achieves the efficacy of leading systemic treatments without presenting safety, drug interaction or toxicity risks," said James R. Baker Jr., MD, founder and chairman of NanoBio Corporation. "Based on the data, NanoBio will move immediately to initiate plans to begin phase 3 testing of NB-001 in early 2009." The full data set from the phase 2b study will be presented following a standard peer review process.

NB-001 is a proprietary oil-in-water emulsion composed of nanometer-sized droplets that employ a physical process to disrupt the outer lipid membrane of viruses. The droplets traverse the pores and hair follicles of the skin without disrupting normal tissues. These droplets accumulate in the epidermis and dermis where they interact directly with and kill the viral organisms at the site of infection.

"The product's novel mechanism leaves little risk of drug resistance, which is a concern with the systemic antiviral therapies used to treat herpes labialis," said Baker. "This attribute coupled with its safety profile may eventually allow NB-001 to be sold without a prescription. This will be important to those people affected by this disease, since the vast majority of herpes labialis sufferers seek over-the-counter treatments for their cold sores."

NanoBio's pipeline of topical anti-infective products and nasally delivered vaccines are based on the company's novel NanoStat technology, a platform protected by five issued patents, as well as numerous pending filings. The issued patents provide patent protection through 2019, while pending filings would extend protection through 2029.

About NanoBio

NanoBio(R) Corporation is a privately held biopharmaceutical company focused on developing and commercializing anti-infective products and mucosal vaccines derived from its patented NanoStat(TM) technology platform. The company's lead product candidates are treatments for herpes labialis (cold sores), onychomycosis (nail fungus), MRSA and mucosal vaccines for influenza and hepatitis B. The company's headquarters and laboratory facilities are located in Ann Arbor, Mich.

NanoBio Corporation
http://www.nanobio.com
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15:54 - 2008-Mar-18 - comments {0} - post comment


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